嵟怴偺尋媶徯夘

[ 儕儕乕僗丗 2020.12 ]
撧椙彈巕戝妛棟妛晹 壔妛惗柦娐嫬妛壢 惗暔壢妛椞堟丂搉绮棙梇

丂奆偝傫偼X² + Y² = Z²偑惉傝棫偮僺僞僑儔僗偺掕棟偼偛懚抦偱偡傛偹丅偲偙傠偑丄僼僃儖儅乕梊憐乮偡偱偵徹柧偝傟偰掕棟偱偡偑乯傪偛懚抦偱偟傚偆偐丅側傫偲Xⁿ + Yⁿ = Zⁿ偼n=3, 4, 5偺n偼懚嵼偟側偄偲偄偆傕偺偱偡丅偙偺徹柧偵偼400擭埲忋偐偐傝傑偟偨丅偁傑傝徹柧偑偱偒側偄偺偱丄悢妛揑側堄枴偼側偄扨弮側僷僘儖偲巚傢傟偰偄偨傕偺偑丄僼僃儖儅乕梊憐傪徹柧偡傞偙偲偱柍娭學偲巚傢傟偰偄偨悢妛偺2偮偺慡偔堎側傞暘栰乮懭墌曽掱幃偲儌僕儏儔乕宍幃乯偑丄幚偼怺偔娭學偟偰偄傞偙偲偑柧傜偐偵側偭偨偺偱偡丅壢妛偺偩偄偛枴偱偁傞丄堎側傞悽奅傪宷偖乽怴偟偄嫶乿偺敪尒偱傕偁偭偨偺偱偡丅
丂惗暔妛偱傕偙偺傛偆偵丄偦傟傑偱峫偊傜傟偰傕偄側偐偭偨傕偺偑寢傃偮偔偙偲偑搙乆偁傝傑偡丅偨偲偊偽丄崱偱偼巹偨偪偺堚揱忣曬傪扴偆暔幙偼乽妀巁乿DNA偱偁傞偙偲偼奆偝傫偛懚抦偱偡偑丄傎傫偺100擭慜偼丄僞儞僷僋幙偙偦偑堚揱忣曬傪扴偭偰偄傞偲婜懸偝傟偰偄傑偟偨丅偹偽偹偽偟偰埖偄偵偔偔屄惈偑側偄傛偆偵尒偊傞妀巁偑堚揱暔幙偱偁傞偲偄偆偙偲偼丄嫵壢彂偵彂偐傟偰偄傞傾儀儕乕偺攛墛憃媴嬠偺幚尡傗丄僴乕僔乕丒僠僃僀僗偺僼傽乕僕姶愼幚尡偺惉壥偑弌傞傑偱偼丄側偐側偐擣傔傜傟傑偣傫偱偟偨丅

丂挿擭尋媶傪偟偰偄傞偲丄彫偝偄偱偡偑丄巚偄偑偗偢偙偺傛偆側宱尡傪偟傑偡丅撧椙彈巕戝偵晪擟偟偰憗傗15擭偵側傠偆偲偟偰偄傑偡丅晪擟屻2擭栚偵懖尋攝懏偝傟偨楅栘偝傫偲嵶乆偲巒傔偨僋儔僗儕儞廤崌場巕堚揱巕乮CALM乯偵拲栚偟偨尋媶偐傜柧傜偐偵偱偒偨丄嵶朎撪暔棳婡峔偲敀寣昦偲偺娭學偑偒偭偐偗偲側傝丄嬤婨戝妛堛妛晹偺寣塼撪壢偺愭惗偨偪偲偺嫟摨尋媶傊偲敪揥偟傑偟偨乮堷梡暥專侾乯丅2010擭偺峔憐偐傜10擭嬤偔偐偐傝傑偟偨偑丄2020擭偺7寧偵丄峈惛恄昦栻僋儘儖僾儘儅僕儞乮CPZ乯偼媫惈敀寣昦偺帯椕栻偲側傝偊傞偙偲傪曬崘偡傞偙偲偑偱偒傑偟偨丅偙偺偙偲偼丄偙傟傑偱塽妛揑偵乽CPZ偱帯椕偟偰偄傞姵幰偺偑傫偵傛傞巰朣棪偼掅偄乿偲偼尵傢傟偰偄偨傕偺偺丄偼偭偒傝偲偼偝傟偰偄側偐偭偨偙偲偱偡丅儅僂僗偺幚尡偲丄婛懚栻偺姵幰偝傫傊偺墳梡傪敽偭偨戝曄嫽枴怺偄寢壥偩偲崅偔昡壙偝傟岞昞偲側傝傑偟偨乮堷梡暥專俀乯丅崱夞偼偙偺尋媶偵偮偄偰娙扨偵偛徯夘偝偣偰偔偩偝偄丅

丂峈惛恄昦栻偺僋儘儖僾儘儅僕儞乮CPZ乯偼1950擭偵奐敪偝傟偨嵟弶偺峈惛恄昦栻偱丄婛偵50擭埲忋傕摑崌幐挷徢傪娷傓惛恄幘姵帯椕偵巊傢傟偰偄傞栻偱偡丅悽奅曐寬婡娭偺昁恵堛栻昳偺儕僗僩偵嵹偭偰偄偰丄寬峃僔僗僥儉偱昁梫偲偝傟傞乽嵟傕埨慡偱嵟傕岠壥揑側栻乿偲偟偰丄惛恄堛妛巎偺戝偒側恑曕偺堦偮偲偝傟偰偄傑偡丅CPZ偼惛恄幘姵帯椕偵壛偊偰丄億儖僼傿儕儞徢丄攋彎晽丄廳搙偺晄埨丄惛恄昦惈峌寕惈丄擄帯惈偺偟傖偭偔傝丄廳搙偺揻偒婥/歲揻丄晄柊徢丄廳搙偺憕醳側偳偺帯椕偵傕梡偄傜傟傑偡丅
丂偙偺傛偆側懡嵤側帯椕岠壥偺儊僇僯僘儉傪扵傞偨傔偵丄CPZ偑偳偺傛偆側摥偒傪偡傞偺偐偺夝愅傕側偝傟偰偄傑偡丅偙傟傑偱偺尋媶偐傜丄恄宱宯偺廳梫側庴梕懱傪娷傓丄僪乕僷儈儞庴梕懱丄僙儘僩僯儞庴梕懱丄僸僗僞儈儞庴梕懱丄傾僪儗僫儕儞庴梕懱丄儉僗僇儕儞惈傾僙僠儖僐儕儞庴梕懱偺婡擻傪慾奞偟傑偡丅偝傜偵丄CPZ 偼僋儔僗儕儞埶懚惈偺桝憲彫朎宍惉傪慾奞偡傞偲偄偆曬崘傕偁傝傑偟偨偑丄偦偺屻偺揥奐偼曬崘偝傟偰偄傑偣傫偱偟偨丅
丂偝傜偵丄塽妛挷嵏偐傜CPZ偱帯椕偟偰偄傞姵幰偺偑傫偵傛傞巰朣棪偺掅偝偑柧傜偐偲側傝丄CPZ偵峈偑傫岠壥偑偁傞偺偱偼側偄偐偲悇掕偝傟偰偄傑偟偨偑丄壢妛揑側徹柧偼側偝傟偰偼偄傑偣傫偱偟偨丅

丂楅栘偝傫偼CALM堚揱巕偑AF10堚揱巕偲梈崌偟偨CALM-AF10偑敀寣昦傪堷偒婲偙偡偙偲偵拝憐傪摼偰丄乽嵶朎撪暔棳婡峔偲敀寣昦偲偵壗偐娭學乿偑偁傞偺偱偼側偄偐偲壖愢傪棫偰丄CALM堚揱巕寚懝儅僂僗傪嶌傝弌偟夝愅偟傑偟偨丅徻偟偔偼偙偺HP偺2015擭偺巹偺尨峞傪嶲徠偟偰偔偩偝偄丅/rigaku/Research/201508.html丅
丂偦偺嵺偵嫟摨尋媶傪峴偭偨揷拞愭惗丄棅愭惗乮尰丒嬤婨戝妛堛妛晹寣塼撪乯偲偙偺傾僀僨傾傪偝傜偵敪揥偝偣丄惓忢寣塼嵶朎撪偱偺儕儞巁壔峺慺妶惈傪帩偮庴梕懱偺嵶朎撪暘晍傊偺娭梌偺寢壥傪岞昞偟傑偟偨乮堷梡暥專侾乯丅偦偺屻丄偙偺傾僀僨傾傪敀寣昦帯椕偵峀偘傛偆偲尋媶傪懕偗傑偟偨丅帯椕傪擮摢偵抲偔偲丄堚揱巕寚懝偲偄偆傛傝偼丄栻嵻偵傛傞嵶朎撪暔棳婡峔偺偐偔棎丒慾奞傪梡偄偨夝愅傪栚巜偟丄偦偺拞偱乽CPZ 偼僋儔僗儕儞埶懚惈偺桝憲彫朎宍惉傪慾奞偡傞偲偄偆曬崘乿偵拲栚偟偰幚尡傪峴偄傑偟偨丅

丂敀寣昦嵶朎偼尨場堚揱巕偺婡擻偵埶懚偟偰憹怋偟傑偡丅敀寣昦偺尨場偱偁傞峆忢揑側僠儘僔儞僉僫乕僛妶惈傪帩偮KIT傗FLT3偺曄堎宆庴梕懱傪帩偮敀寣昦嵶朎偼丄CPZ偱張棟偡傞偲憹怋慾奞偑堷偒婲偙偝傟巰朣偡傞偙偲傪尒偮偗傑偟偨丅偦偙偱CPZ偺摥偒偺偆偪乽壗偑乿敀寣昦嵶朎偺憹怋傪梷偊偨偺偐傪扵傝傑偟偨丅
丂CPZ埲奜偺僪乕僷儈儞庴梕懱偲僙儘僩僯儞庴梕懱偺慾奞嵻傪梡偄傞偲丄CPZ偺傛偆側敀寣昦嵶朎偺憹怋慾奞岠壥偼尒傜傟側偄偙偲偐傜丄偙傟傜偺庴梕懱傪夘偟偨嶌梡偱偼側偄偲峫偊傜傟傑偡丅堦曽丄CPZ 偼僋儔僗儕儞埶懚惈偺桝憲彫朎宍惉傪慾奞偡傞偲偄偆曬崘偵拝栚偟偰丄敀寣昦嵶朎偱僋儔僗儕儞廤崌場巕偺CALM偺敪尰傪梷惂偝偣傞張棟乮CALM僲僢僋僟僂儞朄乯傪峴偆偲丄CPZ張棟偲摨條偵憹怋慾奞偑堷偒婲偙偝傟巰朣偟傑偟偨丅傑偨CPZ張棟偟偨嵶朎撪偱偼丄CALM偺mRNA検偼曄傢傝傑偣傫偱偟偨偑丄僞儞僷僋幙検偼戝偒偔尭彮偡傞偙偲乮東栿屻廋忺乯偑暘偐傝傑偟偨丅偝傜偵CPZ張棟偲CALM僲僢僋僟僂儞偲偱偼丄敀寣昦傪堷偒婲偙偡KIT傗FLT3偺曄堎宆庴梕懱偺嵶朎撪偺嬊嵼偑偍偐偟偔側偭偰偄傑偟偨丅
丂偙傟傜偺偙偲偐傜丄CPZ偼CALM僞儞僷僋幙偺東栿屻廋忺傪夘偟偰丄偦偺検傪尭彮偝偣傞偙偲偱CALM偺婡擻掅壓傪堷偒婲偙偟丄峆忢揑側僠儘僔儞僉僫乕僛妶惈傪帩偮KIT傗FLT3偺曄堎宆庴梕懱偑惓偟偄応強偱摥偗側偔側傞偨傔偵婡擻偑慾奞偝傟偨偙偲偑悇掕偝傟傑偡丅
丂偝偰丄偙傟傜嵶朎儗儀儖偺尭彮偼儅僂僗屄懱偁傞偄偼僸僩偱惉傝棫偮偺偱偟傚偆偐丅徻偟偔偼榑暥傪嶲徠偟偰偄偨偩偒傑偡偑丄儅僂僗偱偼堏怉偵傛傝敀寣昦傪堷偒婲偙偟偨屻偵CPZ傪搳梌偡傞偲敀寣昦偑捈傝傑偡丅傑偨僸僩偺椪彴椺偱偼丄CPZ搳梌偵傛傝敀寣昦嵶朎偑寖尭偡傞偙偲偑敾柧偟傑偟偨丅巆擮側偑傜丄姵幰偝傫偼偙偺屻暿偺尨場偱偍朣偔側傝偵側傝丄CPZ偱敀寣昦偑杮摉偵捈傞偺偐偵偮偄偰偼崱屻偺椪彴尋媶偵備偩偹傞偟偐偁傝傑偣傫丅偟偐偟丄CPZ偼婛偵埨慡惈偑敾柧偟偰偄傞婛懚栻偱偡偺偱丄桳朷側帯椕朄偺壜擻惈偼崅偄偺偱偼偲婜懸偟偰偄傑偡丅

恾侾

恾俀

丂CPZ偼悽奅曐寬婡娭偺昁恵堛栻昳偺儕僗僩偵嵹偭偰偄偰丄寬峃僔僗僥儉偱昁梫偲偝傟傞乽嵟傕埨慡偱嵟傕岠壥揑側栻乿偲偟偰丄惛恄堛妛巎偺戝偒側恑曕偺堦偮偲偝傟偰偄傑偡丅
丂偙偺帯椕岠壥儕僗僩偵乽KIT傗FLT3偺曄堎宆庴梕懱偵傛傞媫惈敀寣昦乿偺崁栚偑壛傢傞擔傕棃傞偺偱偼側偄偐偲婜懸偟偰偄傑偡丅嵶朎撪暔棳桝憲婡峔傪堚揱巕寚懝儅僂僗偱夝愅偡傞偲偄偆挻抧枴側尋媶偑丄峈惛恄昦栻偺僋儘儖僾儘儅僕儞乮CPZ乯偲媫惈敀寣昦偺帯椕偲偄偆丄娭學惈偑梊憐偝傟偰偼偄側偐偭偨暘栰傪寢傃偮偗丄恖椶偺寬峃偵婑梌偡傞偐傕偟傟側偄側偁偲丄柌憐偡傞枅擔偱偡丅

丂枅夞榑暥偺岞昞偵偼嬯楯偡傞偺偱偡偑丄偙偺榑暥偱傕條乆側懱尡傪偝偣偰傕傜偄傑偟偨丅
丂嵟弶偺搳峞帪偵昡壙偟偰偔傟偨僄僨傿僞乕偑丄1夞栚偺夵掕嶌嬈拞偵乽崱搙巕嫙偑惗傑傟傞偺偱丄怴偟偄僄僨傿僞乕偵戙傢傞偐傜乿偲偺楢棈偑偁傝丄偦傫側偙偲傕偁傞傕偺偩偲姶怱偟傑偟偨丅偝傜偵晄岾側偙偲偵丄嵟弶偺搳峞帪偵昡壙偟偰偔傟偨嵏撉幰偲楢棈偑庢傟側偔側偭偨乮丠乯偲偄偆偙偲偱丄1夞栚偺夵掕尨峞偼3恖栚偺怴偟偄嵏撉幰偑壛傢傝傑偟偨丅帺怣傪傕偭偰椪傫偩1夞栚偺夵掕尨峞傊偺曉摎偵偼丄夵掕偝傟偨尨峞偵偼怴偟偄廳戝側寚娮偑偁傝丄嵏撉偑偁傞壢妛嶨帍偱偙偺榑暥傪庴棟偡傞偲偙傠偼偳偙偵傕側偄乮尨暥傑傑丗In addition, the revised version of the manuscript contains a number of new serious flaws which are unacceptable for any peer-reviewed journal.乯偲傑偱崜昡偝傟傑偟偨丅嫟挊幰偺拞偵偼丄偙偙傑偱尵傢傟偰傑偱岞昞偟偨偔側偄偲傑偱偄偆曽傕偄傑偟偨偑丄傛偔撉傓偲丄乽偙偺寢壥偼嶍傟乿丄乽偙偺榑暥傪嶲徠偟傠乿偲嵞嶰側傞傎偳偲巚偊傞揑妋側巜揈傕偁傝丄巹偲揷拞愭惗偲偱奆傪愢摼偟側偑傜幚尡傪峴偄2夞栚偺夵掕尨峞傪憲傞偲丒丒丒怴宆僐儘僫僂僀儖僗偺塭嬁偱庴偗庢偭偨偲偺曉帠偐傜4偐寧娫慡偔壒嵐懣側偟偱丄偝偡偑偵晄嵦戰傪妎屽偟傑偟偨丅
丂庴棟偺儊乕儖偼撍慠棃偨偺偱丄弶傔偼柪榝儊乕儖偐偲媈偭偨偟傑偭偨偙偲傕丄崱偲側偭偰偼妝偟偄巚偄弌偱偡丅傑偨彮偟恖娫偲偟偰惉挿偱偒偨偐側偲彑庤偵巚偭偰偄傑偡丅

堷梡暥專

(1) Shinya Rai, Hirokazu Tanaka, Mai Suzuki, Honami Ogoh, Yasuhiro Taniguchi, Yasuyoshi Morita, Takahiro Shimada, Akira Tanimura, Keiko Matsui, Takafumi Yokota, Kenji Oritani, Kenji Tanabe, Toshio Watanabe, Yuzuru Kanakura, and Itaru Matsumura丂乮2014) Clathrin assembly protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells.
PLoS ONE丂 DOI: 10.1371/journal.pone.0109441.
(2) Shinya Rai, Hirokazu Tanaka, Mai Suzuki, J. Luis Espinoza, Takahiro Kumode, Akira Tanimura, Yasuyoshi Morita, Yoichi Tatsumi, Takafumi Yokota, Kenji Oritani, Toshio Watanabe, Yuzuru Kanakura, and Itaru Matsumura. (2020) Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.
Nature Communications 11(1):4147. doi: 10.1038/s41467-020-17666-8.

乮壓慄偼杮妛強懏幰乯