嵟怴偺尋媶徯夘

[ 儕儕乕僗丗 2016.11 ]
撧椙彈巕戝妛尋媶堾帺慠壢妛宯丂嫵庼丂摗堜峗

丂巹偨偪偺懱撪偵偼丄偨偔偝傫偺峺慺偲屇偽傟傞僞儞僷僋幙偑懚嵼偟丄惗柦妶摦偵昁梫側懡偔偺壔妛斀墳傪峴偭偰偄傑偡丅椺偊偽丄怘帠偱愛庢偟偨怘暔傪徚壔偡傞偙偲傗偦偆偟偰懱撪偵庢傝擖傟偨暔幙傪巊偭偰惗柦妶摦偵昁梫側暔幙傗僄僱儖僊乕傪崌惉偡傞偺傕峺慺偑峴偭偰偄傞偺偱偡丅偙傟傜峺慺偼丄旕忢偵壏榓側忦審偱丄偟偐傕摿掕偺暔幙偺摿掕偺晹埵偵偺傒壔妛斀墳傪桿摫偱偒傞偲偄偆旕忢偵桪傟偨摿惈傪帩偭偰偄傑偡丅峺慺偲摨偠斀墳傪壔妛幰偑帋尡娗撪偱壔妛揑偵峴偆偙偲偼偨偄傊傫崲擄偱偁傝丄偨偔偝傫偺僄僱儖僊乕傗帪娫傪昁梫偲偟偨傝丄偁傞偄偼栚揑偺暔幙偲偼堎側傞晄梫側暔幙傑偱傕惗惉偟偨傝偡傞偺偱偡丅峺慺偑偳偺傛偆側巇慻傒偱偙偺桪傟偨婡擻傪妉摼偟敪尰偟偰偄傞偺偐傪夝柧偡傞偙偲偼丄惗柦偺巇慻傒傪暘巕偺儗儀儖偱抦傞偙偲偑偱偒傞偩偗偱側偔丄昦婥偺偟偔傒傗帯椕偺偨傔偺栻偺奐敪丄偝傜偵偼恖岺峺慺偺傛偆側怴偟偄暔幙偺奐敪偵偮側偑傞偲峫偊偰偄傑偡丅偙偆偟偨峺慺偺尋媶偼丄偙傟傑偱偺傛偆側惗暔妛揑側棫応偩偗偱側偔丄壔妛斀墳偵娭偡傞抦尒傪帩偭偨尋媶幰偑壔妛揑側棫応偐傜尋媶偟側偄偲払惉偱偒側偄壽戣側偺偱偡丅巹偺尋媶幒偱偼丄壔妛揑抦尒偐傜惗懱撪偺峺慺偺摥偔巇慻傒傪尋媶偟偰偄傑偡丅摿偵峺慺偺拞偱傕揝傗摵丄僯僢働儖側偳偺嬥懏僀僆儞傪傕偭偨峺慺乮嬥懏峺慺乯偺尋媶傪峴偭偰偄傑偡丅峺慺偼丄嬥懏僀僆儞傪庢傝崬傓偙偲偵傛傝偝傜偵嫮椡側峺慺偵曄恎偱偒傞偺偱偡丅巹偨偪偺懱撪偱偙偆偟偨嬥懏僀僆儞偑晄懌偡傞偲懱挷偑埆偔側傝傑偡偑丄偙傟傕嬥懏峺慺偲怺偄娭傢傝偑偁傞偺偱偡丅偙偙偱偼丄巹偺尋媶幒偱峴偭偨嵟嬤偺尋媶惉壥傪徯夘偟傑偡丅

僠僩僋儘乕儉P450偵傛傞朏崄娐悈巁壔斀墳偺斀墳婡峔偺夝柧

丂巹偨偪偺懱撪偱偼丄屇媧偱懱撪偵庢傝擖傟偨巁慺傪巊偭偨惗柦妶摦偵昁恵偺暔幙傪崌惉偟偨傝丄媡偵晄梫偵側偭偨暔幙傪暘夝偟偨傝偡傞峺慺偑偁傝傑偡丅偦偺戙昞偑丄僠僩僋儘乕儉P450偲偄偆峺慺偱偡丅偙偺峺慺偼丄変乆恖娫偩偗偱側偔抧媴忋偺傎偲傫偳偺惗暔偑惗柦妶摦偵棙梡偟偰偄傞峺慺偱偡丅偙偺峺慺偼丄恾侾偵帵偡傛偆偵妶惈晹埵乮峺慺偺拞偱斀墳傪峴偆偨傔偺応強乯偵僿儉偲屇偽傟傞暘巕傪傕偪丄僿儉撪偺揝僀僆儞偑峺慺婡擻偺尮偲側偭偰偄傑偡丅僠僩僋儘乕儉P450偵偼偨偔偝傫偺庬椶偑偁傝丄偦傟偧傟偑堎側偭偨婡擻傪帩偭偰偄傑偡丅

恾侾丏僠僩僋儘乕儉P450僇儞僼傽乕偺慡懱峔憿
乮嵍丗椢怓偺儕儃儞偼僞儞僷僋幙丄敄巼怓偱帵偟偨傕偺偑妶惈晹埵偺僿儉乯偲妶惈晹埵偺僿儉偺壔妛峔憿

僠僩僋儘乕儉P450偑峴偆戙昞揑側斀墳偺拞偵丄儀儞僛儞偺傛偆側朏崄懓壔崌暔偺悈巁壔斀墳偑偁傝傑偡丅僠僩僋儘乕儉P450偑峴偆朏崄懓壔崌暔偺悈巁壔斀墳偺椺偲偟偰丄壴偺怓傪寛掕偡傞夁掱偑偁傝傑偡丅懡偔偺壴偼丄傾儞僩僔傾僯儞偲偄偆暔幙偵傛偭偰壴偵怓傪晅偗傑偡丅傾儞僩僔傾僯儞偼丄恾俀偵帵偡傛偆偵3偮偺朏崄娐乮A,B,C乯偐傜側傞暘巕偱偁傝丄峔憿偵傛傝愒乣僆儗儞僕乣巼乣惵偲曄壔偟傑偡丅偙偺怓傪寛傔傞堦斣偺梫場偼丄僼儔儃僲僀僪偺B娐偺悈巁婎乮OH乯偺悢偱偡丅B娐偵悈巁婎偑侾偮偁傞偲僆儗儞僕怓丄俀偮偁傞偲愒怓丄俁偮偁傞偲惵怓傪掓偟傑偡丅偙偺B娐偺悈巁壔斀墳偼丄僠僩僋儘乕儉P450偵傛偭偰峴傢傟偰偄傞偺偱偡丅偙偺椺偐傜傕傢偐傞傛偆偵僠僩僋儘乕儉P450偵傛傞朏崄懓壔崌暔偺悈巁壔斀墳偼丄惗暔偵偲偭偰寚偐偡偙偲偺偱偒側偄嬌傔偰廳梫側斀墳偱偡丅偱偼丄峺慺偼偄偭偨偄偳偺傛偆偵偟偰偙偺斀墳傪偍偙側偭偰偄傞偺偱偟傚偆偐丠

恾俀丏僠僩僋儘乕儉P450偵傛傞朏崄娐悈巁壔斀墳偵傛傞壴偺怓偺寛掕婡峔

偙傟傑偱懡偔偺尋媶偑側偝傟偨寢壥丄僠僩僋儘乕儉P450偺妶惈晹埵偺僿儉偑巁慺偲揹巕偲僾儘僩儞偵傛傝妶惈壔偝傟丄崅巁壔忬懺偺斀墳惈偺崅偄妶惈庬偑惗惉偝傟傞偙偲偑柧傜偐偵偝傟傑偟偨偑丄偦偺屻偙偺妶惈庬偳偺傛偆偵朏崄懓壔崌暔傪悈巁壔偡傞偺偐偼枹夝柧偱偟偨丅巹偺尋媶幒偱偼丄偙偺悈巁壔斀墳偺婡峔傪峺慺偺妶惈庬偺儌僨儖壔崌暔傪恖岺揑偵崌惉偟丄徻嵶偵尋媶偟傑偟偨丅偦偺寢壥丄恾俁偵帵偡傛偆側偙傟傑偱偵側偄斀墳婡峔傪幚尡揑偵採彞偡傞偙偲偵惉岟偟傑偟偨丅巹偨偪偼丄悈巁壔斀墳偺棩懍抜奒偱峺慺偺崅巁壔忬懺偺妶惈庬偲朏崄懓壔崌暔偺娫偱揹巕堏摦偑婲偙傞偙偲傪尒偄偩偟丄偙偺揹巕堏摦偺夁掱偑妶惈庬偲朏崄懓壔崌暔娫偺寢崌惗惉夁掱偲嫟栶偡傞偲偄偆怴偟偄婡峔傪採埬偟傑偟偨丅偙偺怴偟偄婡峔偼丄偙傟傑偱偵曬崘偝傟偨悈巁壔斀墳偵娭偡傞懡偔偺幚尡寢壥傪柕弬側偔愢柧偡傞偙偲偑偱偒傞桞堦偺婡峔偲側傝傑偟偨丅偙偺尋媶惉壥偵娭偡傞榑暥偼丄杮擭搙丄傾儊儕僇壔妛夛帍乮Journal of American Chemical Society乯偵宖嵹偝傟傑偟偨丅傑偨丄傾儊儕僇壔妛夛帍偺宖嵹廡偺儂乕儉儁乕僕偵偍偄偰僶僫乕偲偟偰庢傝忋偘傜傟徯夘偝傟傑偟偨丅偙偺尋媶偼丄巹偺尋媶幒偺M2偺愺崄錆嵤偝傫偑拞怱偲側偭偰峴偭偨惉壥偱偡丅尰嵼丄M1偺暉堜撧旤偝傫偲4擭惗偺愇悈桭棞偝傫偑偝傜偵偙偺惉壥傪敪揥偝偣傞尋媶傪峴偭偰偄傑偡丅

恾俁丏変乆偑採埬偟偨僠僩僋儘乕儉P450偵傛傞朏崄娐悈巁壔斀墳偺婡峔

丂偙偺懠偵傕巹偺尋媶幒偱偼丄敀寣媴偑懱撪偵怤擖偟偨嵶嬠傪寕戅偡傞偨傔偵巊偆師垷墫慺巁乮昚敀嵻偺庡惉暘乯傪崌惉偡傞峺慺乮椺偊偽儈僄儘儁儖僆僉僔僟乕僛丗変乆恖娫偼昚敀嵻偲摨偠暔幙傪懱撪偱嶌傝丄偟偐傕偦傟傪巊偭偰嵶嬠傪寕戅偟偰偄傞偺偱偡乯丄惗暔偺懱撪偱揝僀僆儞偺儕僒僀僋儖偵娭傢傞峺慺乮椺偊偽僿儉僆僉僔僎僫乕僛乯丄抧媴偺拏慺壔崌暔偺僶儔儞僗傪曐偮偨傔偵栶棫偭偰偄傞搚忞嵶嬠拞偺峺慺乮椺偊偽垷徤巁娨尦峺慺乯側偳偺婡峔偺尋媶傕峴偭偰偄傑偡丅偙偆偟偨尋媶偼丄M1偺峳栘堣巕偝傫偲墶揷幯榓巕偝傫丄4擭惗偺擄攇徠戙偝傫偑偑傫偽偭偰峴偭偰偄傑偡丅

丂帺慠偼懡偔偺峺慺傪巊偭偰懡條側惗柦斀墳傪峴偭偰偄傞偨傔丄堦尒旕忢偵暋嶨偱廂廍偑偮偐側偄傛偆偵尒偊傑偡偑丄巹偼偙偆偟偨懡條惈偺拞偵懡偔偺惗柦斀墳傪巟攝偡傞扨弮偱旤偟偄寛傑傝偛偲偑偁傞偲峫偊偰偄傑偡丅崱屻傕峺慺偺婡峔偺尋媶傪捠偟偰丄帺慠偺旤偟偝傪尒偄偩偡偙偲偑偱偒傞傛偆偵尋媶傪懕偗偰偄偒偨偄偲巚偭偰偄傑偡丅

杮尋媶偵娭偡傞嵟嬤偺榑暥

(1) Maaya Asaka and Hiroshi Fujii
Participation of Electron-Transfer Process in Rate-Limiting Step of Aromatic Hydroxylation Reactions by Compound I Models of Heme Enzymes
Journal of American Chemical Society 2016, 138, 8048-8051
http://pubs.acs.org/doi/pdf/10.1021/jacs.6b03223

(2) Toshitaka Matsui, Shusuke Nambu, Celia W. Goulding, Satoshi Takahashi, Hiroshi Fujii, and Masao Ikeda- Saito
Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation
Proceedings of National Academy of Sciences of USA 2016, 113, 3779-3784
http://www.pnas.org/content/113/14/3779

(3) Hiroshi Fujii, Daisuke Yamaki, Takashi Ogura, and Masahiko Hada
The Functional Role of the Structure of the Dioxo-isobacteriochlorin in the Catalytic Site of Cytochrome cd1 for the Reduction of Nitrite
Chemical Science 2016, 7, 2896-2906
http://pubs.rsc.org/en/content/articlepdf/2016/sc/c5sc04825g