嵟怴偺尋媶徯夘

乗婎慴惗暔妛偐傜僸僩偺昦婥偺尨場夝柧傑偱乗

[ 儕儕乕僗丗 2015.08 ]
撧椙彈巕戝妛棟妛晹 壔妛惗柦娐嫬妛壢 惗暔壢妛僐乕僗丂搉绮棙梇

搉绮尋媶幒偱偼丄1屄偺堚揱巕偑側偔側偭偨帪偵丄屄懱傗屄懱傪宍嶌傞嵶朎偺偦傟偧傟偺儗儀儖偱偳偺傛偆側偙偲偑堷偒婲偙偝傟傞偺偐傪挷傋傞偨傔偵帺暘偨偪偺庤偱堚揱巕寚懝儅僂僗傪嶌傝弌偟偰偄傑偡丅偙偺儅僂僗傪梡偄偰丄堚揱巕偺杮棃偺婡擻偲偦偺婡擻堎忢偑堷偒婲偙偡昦婥偵娭偟偰尋媶偟偰偄傑偡丅嵶朎撪偺暔棳桝憲偵娭楢偟偰偄傞偲巚傢傟傞堚揱巕偱丄偐偮僸僩偺昦婥偲偺娭楢偑媈傢傟偰偄傞傕偺傪慖傫偱尋媶懳徾偲偟偰偄傑偡丅偙偙偱偼丄僸僩偺昦婥偲偺娭楢傪柧傜偐偵偟丄嵟嬤岞昞偟偨3偮偺尋媶偵偮偄偰徯夘偟傑偡丅

乮侾乯CALM乮僇儖儉乯偺婡擻掅壓偼傾儖僣僴僀儅乕昦偺梊杊偲側傝偊傞壜擻惈偑偁傞

尋媶偺攚宨丗

嵶朎撪偺暔棳桝憲帪偵桝憲敔偲偟偰巊傢傟傞暘巕傪廤傔傞CALM乮僇儖儉乯偼戝婯柾僎僲儉夝愅偐傜傾儖僣僴僀儅乕徢偺婋尟場巕偲偟偰悇掕偝傟偰偄傑偟偨偑丄杮摉偵婋尟場巕側偺偐丄偳偺條偵偟偰娭梌偡傞偺偐偼偙傟傑偱尋媶偝傟偰偄傑偣傫偱偟偨丅

尋媶惉壥�堄媊丗

搶嫗戝妛栻妛宯尋媶壢偲偺嫟摨尋媶偵傛傝丄CALM乮僇儖儉乯偺掅壓偑傾儖僣僴僀儅乕徢偺尨場暔幙偺傾儈儘僀僪儀乕僞僞儞僷僋幙偺惗惉検傪掅壓偝偣傞偙偲傪怴偨偵敪尒偟傑偟偨乮恾侾乯丅CALM乮僇儖儉乯偺摥偒傪丄嵶朎儗儀儖偲屄懱儗儀儖偲偺椉曽偺幚尡偱幚嵺偵妋擣偟偨悽奅弶偺尋媶偱偡丅崱屻丄CALM乮僇儖儉乯傪夘偡傞傾儖僣僴僀儅乕徢偺敪徢偺夝柧偑恑傔偽丄怴偟偄帯椕栻偺奐敪偵峷專偡傞偙偲偑婜懸偝傟傑偡丅杮尋媶偵偼丄杮妛妛惗偺楅栘杻堖偑嶲夋偟傑偟偨丅側偍杮尋媶偼暥晹壢妛徣壢妛尋媶旓曗彆嬥丄撧椙彈巕戝妛僾儘僕僃僋僩宱旓側偳偺彆惉傪庴偗偰峴傢傟傑偟偨丅偙偺尋媶惉壥偼丄2014擭偵Nature Communications偵敪昞偟傑偟偨丅

乮俀乯CALM乮僇儖儉乯偑帩偮妀奜攔弌攝楍偲梈崌偡傞偙偲偱僄僺僕僃僱僥傿僢僋場巕偺AF10偑敀寣昦傪堷偒婲偙偡

尋媶偺攚宨丗

AF10偼CALM乮僇儖儉乯偲梈崌偟偰CALM-AF10偲側傝敀寣昦傪堷偒婲偙偡偙偲偑抦傜傟偰偄傑偟偨偑丄壗屘CALM乮僇儖儉乯偲梈崌偡傞偙偲偑昁梫側偺偐偼慡偔暘偐偭偰偄傑偣傫偱偟偨丅

尋媶惉壥�堄媊丗

崙棫偑傫尋媶僙儞僞乕尋媶強偲偺嫟摨尋媶偵傛傝丄CALM乮僇儖儉乯暘巕偺婡擻夝愅偐傜丄CALM乮僇儖儉乯偑帩偮妀奜攔弌攝楍乮NES攝楍乯偺傒偲AF10偺梈崌懱偱敀寣昦偑堷偒婲偙偝傟傞乽傑偭偨偔怴偟偄敀寣昦敪徢婡峔乿傪敪尒偟傑偟偨乮恾2乯丅偙偺敪尒偵傛傝丄 妀奜攔弌婡峔偺婡擻慾奞傪巜昗偲偡傞怴偟偄帯椕栻偺奐敪偵峷專偡傞偙偲偑婜懸偝傟傑偡丅杮尋媶偵偼丄杮妛妛惗偺楅栘杻堖偑嶲夋偟傑偟偨丅側偍杮尋媶偼暥晹壢妛徣壢妛尋媶旓曗彆嬥丄撧椙彈巕戝妛僾儘僕僃僋僩宱旓側偳偺彆惉傪庴偗偰峴傢傟傑偟偨丅偙偺尋媶惉壥偼丄2014擭偵Cancer Science偵敪昞偟傑偟偨丅

乮俁乯晄柧偱偁偭偨旂晢偑傫傪梷偊崬傓婡峔傪夝柧

尋媶偺攚宨丗

娻堚揱巕曄堎傪堷偒婲偙偡抜奒偲丄娻嵶朎偺朶憱傪懀恑偡傞2偮偺抜奒傪宱偰旂晢偑傫偲側傝傑偡 丅戝婯柾堚揱巕夝愅偱丄扙儕儞巁壔峺慺PP6 偺幐妶偑娻嵶朎偺朶憱懀恑梫場岓曗偲偟偰拲栚偝傟巒傔傑偟偨偑妋徹偼偁傝傑偣傫偱偟偨丅PP6偼嵶朎撪偺暔棳桝憲偺攝憲僙儞僞乕偱偁傞僑儖僕懱偺婡擻偲傕娭楢偑偁傞偲偝傟偰偄傑偟偨丅

尋媶惉壥�堄媊丗

媨忛導棫偑傫僙儞僞乕尋媶強偲偺嫟摨尋媶偱丄PP6偑側偔側傞偲朶憱傪懀恑偡傞栻嵻側偟偵娻偑惗偠傞偙偲傪柧傜偐偵偟傑偟偨丅 PP6 偼旂晢娻嵶朎偺朶憱傪梷偊崬傓僽儗乕僉栶偺乽娻梷惂堚揱巕乿偱偁傞偙偲偑弶傔偰帵偝傟傑偟偨 乮恾 3乯丅 偙偺敪尒偵傛傝丄 扙儕儞巁壔峺慺偺妶惈懀恑傪巜昗偲偡傞怴偟偄偑傫梊杊丒帯椕栻偺奐敪傗恌抐偵峷專偡傞偙偲偑婜懸偝傟傑偡丅
杮尋媶偵偼丄杮妛妛惗偺彫壨曚攇丄娸杮埢巕丄楅栘杻堖偑嶲夋偟傑偟偨丅
側偍杮尋媶偼暥晹壢妛徣壢妛尋媶旓曗彆嬥丄撧椙彈巕戝妛僾儘僕僃僋僩宱旓側偳偺彆惉傪庴偗偰峴傢傟傑偟偨丅偙偺尋媶惉壥偼丄2015擭偵Oncogene偲Cancer letters偺僆儞儔僀儞斉偵偰愭峴敪昞偟傑偟偨丅

娭楢榑暥

侾乯Kunihiko Kanatsu, Yuichi Morohashi, Mai Suzuki, Toshio Watanabe, Taisuke丂Tomita and Takeshi Iwatsubo. (2014)
Decreased CALM expression reduces Ab42 to total Ab ratio through clathrin-mediated endocytosis of g-secretase.
Nature Communication , DOI: 10.1038/ncomms4386.
http://www.readcube.com/articles/10.1038/ncomms4386

俀乯Kunihiko Kanatsu, Yukiko Hori, Sho Takatori, Toshio Watanabe, Takeshi Iwatsubo, and Taisuke Tomita. (2016)
Partial loss of CALM function affects g-secretase-mediated Ab42 production and amyloid deposition in vivo.
Human Molecular Genetics,丂in press.
http://hmg.oxfordjournals.org/content/early/2016/07/20/...

俁乯Mai Suzuki, Kazutsune Yamagata, Mika Shino, Yukiko Aikawa, Koichi Akashi, Toshio Watanabe and Issay Kitabayashi. (2014)
Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia.
Cancer Science, 105, 315-323.
http://onlinelibrary.wiley.com/doi/10.1111/cas.12347/abstract...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317939/

係乯Katsuhisa Hayashi, Yuki Momoi, Nobuhiro Tanuma, Ayako Kishimoto, Honami Ogoh, Hiroyuki Kato, Mai Suzuki, Yoshimi Sakamoto, Yui Inoue, Miyuki Nomura, Hiroshi Kiyonari,丂Masato Sakayori, Kayoko Fukamachi, Yoichiro Kakugawa, Yoji Yamashita, Shigemi Ito, Ikuro Sato, Akira Suzuki, Miki Nishio, Masami Suganuma, Toshio Watanabe and Hiroshi Shima. (2015)
Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA.
Oncogene 34, 4647-4655.
http://www.nature.com/onc/journal/v34/n35/full/onc2014398a.html
http://www.ncbi.nlm.nih.gov/pubmed/25486434

俆乯Hiroyuki Kato, Nobuhiro Tanuma, Katsuhisa Hayashi, Koreyuki Kurosawa, Yuki Momoi, Honami Ogoh, Masato Sakayori, Yoichiro Kakugawa, Yoji Yamashita, Koh Miura, Shigemi Ito, Ikuro Sato, Natsuko Chiba, Toshio Watanabe and Hiroshi Shima. (2015)
Loss of Protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.
Cancer Letters, 365, 223-228.
http://www.sciencedirect.com/science/article/pii/S0304383515003729