怉栰尋媶幒 尋媶奣梫

墳梡旝惗暔妛尋媶幒偼丆GABA偺尋媶傪偟偰偄傑偡丏

gad_reaction.jpgGABA偼傾儈僲巁偺堦庬偱偡丏僌儖僞儈儞巁偑扙扽巁偝傟傞偙偲偱嶌傜傟傑偡乮恾1乯

丂GABA偼丆崅摍摦暔偺恄宱宯偱偼庡梫側梷惂惈恄宱揱払暔幙偲偟偰摥偔偲偰傕廳梫側暔幙偱偡丏偦偺嶌梡偼丆GABA偵摿堎揑側庴梕懱乮GABAA丆GABAB丆GABAC乯偵寢崌偡傞偙偲偱偍偒傞偲偝傟傑偡丏GABA帺恎偼丆梓棻偵棴傔傜傟偰丆怣崋偑偁傟偽丆堦婥偵曻弌偝傟傞偲偝傟偰偄傑偡丏偱傕丆偙傟偼恄宱宯偱偺榖偱丆旕恄宱宯偱偺栶妱偼夝偭偰偄傑偣傫丏

  丂GABA偺摥偒偼懡婒偵傢偨傝傑偡丏寣埑忋徃梷惂岠壥丆棙擜嶌梡丆惉挿儂儖儌儞桿敪嶌梡側偳偑曬崘偝傟偰傑偡丏傑偨丆GABA偑側偄偲釤釖偺傛偆側敪嶌傪婲偙偟傑偡丏GABA偑懡偡偓傞偲偆偮昦忬懺偵側傝傑偡丏摉尋媶幒偱偼丆GABA偺摥偒傪惂屼偡傞偙偲偵娭怱偑偁傝傑偡丏


丂偳偺傛偆側宍偱GABA偺摥偒傪惂屼偱偒傞偺偱偟傚偆偐丠
丂丂a. GABA偺崌惉宯偺惂屼
丂丂b. GABA偺曻弌偺惂屼
丂丂c. GABA偺庴梕懱傊偺寢崌偺惂屼
丂丂d. GABA偑庴梕懱傊寢崌偟偰偐傜偺怣崋偺揱払宱楬傪惂屼
側偳丆偄傠偄傠偲偁傞偱偟傚偆丏偦傟偧傟堦挿堦抁偑偁傝傑偡丏傑偨丆栻棟岠壥傪弌偡偨傔偵偼丆堦偮偩偗偺慖戰媄偱偼偄偗傑偣傫丏尰嵼偺庡棳偼丆c 偺傛偆偱偡偑丆彊乆偵b偵傕拲堄偑偄偭偰偄傑偡丏

摉尋媶幒偱偼丆媶嬌揑側僠儑僀僗偱偁傞a 偵徟揰傪偁偰偰偄傑偡丏a 偺尋媶偼寢峔崲擄偱偡丏傑偢丆峺慺傪埖偆偙偲偱丆庴梕懱偺傛偆偵嵶朎偵敪尰偡傞偩偗偱偦偺嶌梡傪奯娫尒傞偙偲偼偱偒傑偣傫丏峺慺偺惛惢偑昁梫偵側傝傑偡丏

丂偦偙偱丆婎杮揑偵偼丆惛惢偺娙曋偝傪栚巜偟丆旝惗暔偵傛傞敪尰宯傪峔抸偟丆旝惗暔偺攟梴偐傜惛惢丆偦偟偰丆惗壔妛揑尋媶偲偄偆棳傟偱巇帠傪恑傔傑偡丏

丂寢嬊丆堚揱巕乮暘巕惗暔妛乯偐傜僞儞僷僋幙乮惗壔妛丒峔憿惗暔妛乯偺椞堟傪尋媶偡傞偙偲偵側傝傑偡丏

GABA崌惉峺慺偺敪尰偲惛惢

GABA崌惉峺慺偺敪尰偲惛惢
惗暔庬 敪尰GAD偺実懷 敪尰GAD偺廻庡
摦暔 GAD65 僷儞岞曞
  GST-GAD67 戝挵嬠

His6-GAD67  僷儞峺曣
僷儞峺曣 His6-GAD1   戝挵嬠
崓嬠 His6-GAD6   崓嬠




摦暔桼棃偺僌儖僞儈儞巁僨僇儖儃僉僔儔乕僛乮GAD乯偺戝挵嬠偵偍偗傞敪尰宯傪傕偭偰偄傑偡丏

GAD65偲GAD67偺傾僀僜僼僅乕儉偺栶妱偺夝柧

GAD偵嶌梡偡傞僗僷僀僗乮崄恏椏乯丒惗栻丒僴乕僽偺摥偒傪尋媶偟偰傑偡丏
乮偆偮昦側偳偺帯椕栻丒枴妎夵曄暔幙偲側傝摼傑偡乯

旝惗暔桼棃偺GAD偺慻姺偊懱僞儞僷僋幙偺敪尰宯傪傕偭偰偄傑偡丏
(寬峃怘昳偺桳岠惉暘偲偟偰偺GABA偺嫙媼尮偲側傝摼傑偡乯

峺曣桼棃偺GAD1偺峔憿偲婡擻偺夝愅

崓嬠桼棃偺GAD偺峔憿偲婡擻偺夝愅
擕巁嬠桼棃偺GAD偼丆擕巁嬠偺巁懴惈婡峔偵娭梌偟偰偄傑偡丏
僷儞峺曣桼棃偺GAD1偼丆僷儞峺曣偺巁懴惈婡峔偵娭梌偟偰偄傑偡丏
 
  
徚壔婍宯慻怐乮堓丒挵丒岥峯乮旂晢乯丒愩乯偵偍偗傞GAD偺婡擻夝愅
乮枴妎偺僔僌僫儖揱払丆枴妎夵曄暔幙偺扵嶕丆尭墫怘昳偺奐敪乯

摉尋媶幒偵偍偄偰丆徚壔婍宯慻怐偵GAD偺懚嵼傪柧傜偐偵偟偨丏摿偵丆愩偺枴錛嵶朎偵偰GAD偑敪尰偟偰偍傝丆偦偺枴妎偺忣曬揱払婡峔傊偺娭梌傪柧傜偐偵偟傛偆偲偟偰偄傞丏

GABA埲奜偺尋媶傕偟偰偄傑偡丏
俀丏僸僗僞儈儞崌惉峺慺偺峔憿偲婡擻偺夝愅
乮僉乕儚乕僪丗HDC丆僸僗僞儈儞丆傾儗儖僊乕丆歜懅丆堓巁暘斿丆怘拞撆丆旤敀岠壥丆堢栄嶌梡丆東栿屻廋忺丆妶惈壔乯
僸僩桼棃偺僸僗僠僕儞僨僇儖儃僉僔儔乕僛乮HDC乯偺戝挵嬠偵偍偗傞敪尰宯傪傕偭偰偄傑偡丏

HDC偺妶惈惂屼場巕傪僗僷僀僗丒惗栻丒僴乕僽傛傝扵嶕偟偰偄傑偡丏
乮峈傾儗儖僊乕嵻丒峈堓捵釃嵻丒峈歜懅嵻偺奐敪乯

HDC偺妶惈敪尰婡峔偺尋媶
HDC偼C枛抂栺150巆婎偑愗抐偝傟傞偙偲偱妶惈壔偝傟傞丏偦偺妶惈壔偵娭偡傞婡峔偼傑偩姰慡偵偼棟夝偝傟偰偍傜偢丆惗懱撪偱偺妶惈敪尰傪惂屼偡傞揰偱尋媶傪恑傔偰偄傞丏

俁丏僾儘僥傾乕僛丒徚壔峺慺偵偮偄偰偺尋媶
 
 丒 僇儖儃僉僔儁僾僠僟乕僛Y偺峔憿偲婡擻偺尋媶 
 丒 攡庰惢憿屻偺捫偗攡偺桳岠棙梡偵偮偄偰偺尋媶 
丒  僉僲僐偺嶻惗偡傞徚壔峺慺偺尋媶 

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